Hydroxypropyl Beta-Cyclodextrin (HPβCD)
CAS 128446-35-5
- CAS number
- 128446-35-5
Supply of Hydroxypropyl Beta-Cyclodextrin
- Grades
- Pharmacopoeial parenteral grade (EP hydroxypropylbetadex / USP-NF) with low endotoxin, oral and topical pharmaceutical grades, and technical grades, each specified by degree of molar substitution.
- Packaging
- 1 kg, 5 kg and 25 kg containers or fibre drums with double PE liner
- Documents
- CoA, SDS and TDS on request; certificate of origin where the destination requires it.
- Delivery
- Worldwide, including the United States, Canada, the United Kingdom, Germany and the rest of the EU, the United Arab Emirates, India, Singapore, Malaysia and Australia. Quoted EXW, FOB, CIF or DAP.
Hydroxypropyl beta-cyclodextrin is a ring-shaped molecule made from starch. The inside of the ring repels water and the outside attracts it, so it can hold a drug that does not dissolve in water inside the ring and carry it into solution. That makes it possible to turn such drugs into injections, eye drops and oral solutions. It is also the odour-trapping ingredient in some fabric fresheners.
Technical details
Hydroxypropyl beta-cyclodextrin is a derivative of beta-cyclodextrin, a ring of seven glucose units produced enzymatically from starch. The ring's cavity is hydrophobic and its exterior hydrophilic, so it forms inclusion complexes with poorly soluble molecules and carries them into aqueous solution. Hydroxypropylation disrupts the hydrogen bonding that limits the parent cyclodextrin to about 18 g per litre, raising solubility above 500 g per litre and making the material suitable for parenteral use. The degree of molar substitution changes complexation behaviour, so it is fixed in the specification. Ehlinar supplies parenteral, oral and technical grades.
Appearance: White to off-white amorphous powder; very soluble in water, above 50% w/v.
Applications
How we supply
- Certificate of Analysis (CoA), lot-specific where available
- Safety Data Sheet (SDS / MSDS)
- Technical Data Sheet (TDS)
- Certificate of Origin / Certificate of Conformity
Independent third-party inspection can be arranged on request, with the agency and scope agreed per trade. Representative samples can be requested for qualification, subject to supplier availability. We recommend incoming quality control against the agreed CoA.
Quoted on standard Incoterms (e.g. EXW, FOB, CIF, DAP) as agreed per trade. Delivery region, packaging and grade are confirmed per quote.
Documents and services above are subject to supplier availability and confirmed per quote; nothing here is an offer.
Typical / indicative values — not a binding specification
| Property | Typical |
|---|---|
| Water solubility | Above 500 g/L |
Also known as
HPβCD · HP-β-CD · 2-Hydroxypropyl-β-cyclodextrin · Hydroxypropylbetadex
Frequently asked questions
- Why not use plain beta-cyclodextrin?
- Beta-cyclodextrin itself dissolves only to about 18 g per litre and is not suited to injection. The hydroxypropyl derivative is far more soluble and is the form used in parenteral products.
- What does molar substitution mean for my formulation?
- It is the average number of hydroxypropyl groups per glucose unit. It affects solubility and how strongly a given drug is complexed, so a formulation developed on one substitution range should stay on it.
- Which grade for injection?
- The pharmacopoeial parenteral grade, with low endotoxin and the documentation a regulated filing needs. Tell us the pharmacopoeia and the substitution range when you ask for a quote.
Enquire about Hydroxypropyl Beta-Cyclodextrin
Related products
Figures and identifiers here are compiled from public references and provided for general information; they are indicative, not a specification. See all products.