D-Mannitol
CAS 69-65-8 C6H14O6
- CAS number
- 69-65-8
- EC number
- 200-711-8
- Formula
- C6H14O6
- Molar mass
- 182.17 g/mol
- HS code
- 2905.43
Supply of D-Mannitol
- Grades
- Pharmacopoeial grades (USP / EP / JP) as powder, granular and spray-dried direct-compression material, low-endotoxin parenteral grade for injectables and freeze-drying, and food grade (E421).
- Packaging
- 25 kg bags or fibre drums with PE liner · Parenteral grade: double PE liner in fibre drum
- Documents
- CoA, SDS and TDS on request; certificate of origin where the destination requires it.
- Delivery
- Worldwide, including the United States, Canada, the United Kingdom, Germany and the rest of the EU, the United Arab Emirates, India, Singapore, Malaysia and Australia. Quoted EXW, FOB, CIF or DAP.
D-Mannitol is a sugar alcohol found naturally in mushrooms, seaweed and many fruits. Medicine makers use it to give freeze-dried injections a firm cake that dissolves quickly, and as a filler in tablets, because it tastes sweet and cool and does not absorb moisture. It is also a sweetener in sugar-free sweets and chewing gum, and hospitals use it as an infusion to reduce swelling in the brain.
Technical details
D-Mannitol is a six-carbon sugar alcohol, a stereoisomer of sorbitol, produced by hydrogenating fructose-rich sugars or extracted from seaweed. In freeze-drying it crystallises during freezing and forms a mechanically stable cake, so it is paired with an amorphous stabiliser: trehalose or sucrose protects the protein, and mannitol gives the cake its structure. It is non-reducing and non-hygroscopic, so it does not take part in Maillard reactions with amine-bearing drugs and does not draw moisture into a tablet. Ehlinar supplies pharmacopoeial, parenteral and food grades.
Appearance: White crystalline powder or granules; odourless, with a sweet, cooling taste; freely soluble in water; not hygroscopic.
Applications
How we supply
- Certificate of Analysis (CoA), lot-specific where available
- Safety Data Sheet (SDS / MSDS)
- Technical Data Sheet (TDS)
- Certificate of Origin / Certificate of Conformity
Independent third-party inspection can be arranged on request, with the agency and scope agreed per trade. Representative samples can be requested for qualification, subject to supplier availability. We recommend incoming quality control against the agreed CoA.
Quoted on standard Incoterms (e.g. EXW, FOB, CIF, DAP) as agreed per trade. Delivery region, packaging and grade are confirmed per quote.
Documents and services above are subject to supplier availability and confirmed per quote; nothing here is an offer.
Typical / indicative values — not a binding specification
| Property | Typical |
|---|---|
| Melting point | ~165–169 °C |
| Water solubility | Freely soluble |
Also known as
Mannitol · Mannite · E421 · Manna sugar
Frequently asked questions
- Why is mannitol used together with trehalose in freeze-drying?
- They do different jobs. Trehalose stays amorphous and protects the protein; mannitol crystallises and gives the dried cake strength and a clean appearance. Used alone, mannitol can crystallise away from the protein and leave it unprotected, which is why the two are combined.
- Which grade for tablets?
- Spray-dried or granular grades for direct compression; fine powder grades for wet granulation. For injectables and freeze-drying, specify the low-endotoxin parenteral grade.
- Is mannitol the same as sorbitol?
- No. They are stereoisomers with the same formula, but sorbitol is hygroscopic and mannitol is not, so they behave very differently in tablets and dry products. They have different CAS numbers.
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Related products
Figures and identifiers here are compiled from public references and provided for general information; they are indicative, not a specification. See all products.